The patella is normally pulled over the end of the femur in a straight line by the quadriceps muscle. Patients with chondromalacia patella regularly have abnormal patellar monitoring toward the outer side of the femur. This somewhat off-kilter pathway allows the undersurface of the patella to grate along the femur, causing chronic suffering and inflammation. Certain individuals are predisposed to build up chondromalacia patella: females, knock-kneed or flat-footed runners, or those with an shaped patellar undersurface unusually.. Chondromalacia Patella Causes Chondromalacia patella can occur for unknown reasons, nonetheless it usually is caused by improper tracking of the kneecap as it slides over the bone of the thigh .In addition, it has been observed that pregnant women suffering from MS do better during pregnancy when their hormone levels are high. The group headed by Dr Stated Ghandour had currently demonstrated the protective effect of testosterone on oligodendrocytes . For this study, the researchers firstly induced chronic demyelination of the nerve fibers in the brain of mice. To do this, they added cuprizone, a molecule that sequesters copper, with their diet. The mice after that exhibited chronic demyelination, analogous to that observed through the progressive stage of MS.