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Arsenic trioxide feasible in low-, high-risk severe promyelocytic leukaemia By Shreeya Nanda, Senior medwireNews Reporter The use of arsenic trioxide rather than idarubicin in combination with all-trans retinoic acid is a feasible option in individuals with acute promyelocytic leukaemia, of risk level regardless, suggests a phase III trial. ATRA plus arsenic trioxide led to significant reductions in the rate of relapse and supportive care needs weighed against the chemotherapy-based regular of care, with similar rates of complete remission and general survival along with comparable standard of living methods.