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Following administration, sufferers in the best dose groups acquired reductions in viral load as high as approximately 0.7 log10 and mean reductions when compared to placebo group of approximately 0.4 log10 that had been significant statistically. In this study, two topics with pre-existing drug-level of resistance mutations exhibited greater than 0.5 log10 reductions from baseline following PA-457 treatment. PA-457 was well tolerated at all dosage levels in the Phase I/II research. At the IAS Conference, a far more complete analysis of the info was provided, including era of a model allowing detailed examination of the correlation between PA-457’s pharmacokinetics and the drug’s antiviral effect.